Pharmacological Action
Tetracycline mankhwala. Zimagwira ntchito pomangiriza ku 30S subunit ya bakiteriya ribosome, kusokoneza mapangidwe a intiation complex pakati pa RNA ndi mRNA, ndikuletsa kufalikira kwa peptide, motero kulepheretsa mapuloteni. Izi zimachepetsa msanga kukula ndi kubereka kwa bakiteriya. Ndiwothandiza kwambiri polimbana ndi mabakiteriya ambiri a Gram-oipa ndi a Gram-wopanda mabakiteriya. Tizilombo toyambitsa matenda titha kukhala-kusagwirizana ndi ma tetracycline ena.
Tetracycline mankhwala. Amagwiritsidwa ntchito pochiza matenda oyambitsidwa ndi Escherichia coli, Salmonella, Pasteurella, ndi Chlamydia mu ziweto ndi nkhuku.
Mlingo ndi Kuyang'anira:
Mlingo wotengera Oxytetracycline: 50 mg pa kilogalamu ya kulemera kwa thupi, wothira madzi akumwa, kutumikiridwa kamodzi patsiku kwa masiku atatu mpaka 5.
Zoyipa:
Kugwiritsa ntchito nthawi yayitali kungayambitse matenda a superinfection komanso kuwonongeka kwa chiwindi.
Kusamalitsa:
(1) Osagwiritsa ntchito nyama zomwe zimadziwika kuti ndi hypersensitivity kwa tetracyclines. Osapereka nthawi imodzi ndi mankhwala okhala ndi calcium, chitsulo, kapena ayoni ena achitsulo.
(2) Pewani kugwiritsa ntchito nthawi imodzi ndi zinthu zamchere kwambiri.
(3) Osagwiritsa ntchito nyama zomwe zili ndi vuto lalikulu la chiwindi kapena aimpso.
(4) Gwiritsani ntchito mosamala; pewani kugwiritsa ntchito nthawi yayitali.
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